Human Pot1 OB-fold mutations unleash rampant telomere instability to initiate tumorigenesis

Chromosomal aberrations are a hallmark of human cancers, with complex cytogenetic rearrangements leading to genetic changes permissive for cancer initiation and progression. Protection of Telomere 1 (POT1) is an essential component of the shelterin complex and functions to maintain chromosome stabil...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Gu, Peili, Wang, Yang, Bisht, Kamlesh K., Wu, Ling, Kukova, Lidiya, Smith, Eric M., Xiao, Yang, Bailey, Susan, Lei, Ming, Nandakumar, Jayakrishnan, Chang, Sandy
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383532/
https://ncbi.nlm.nih.gov/pubmed/27869160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.405
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