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High‐level intrathymic thyrotrophin receptor expression in thyroiditis‐prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies

The thyrotrophin receptor (TSHR) A‐subunit is the autoantigen targeted by pathogenic autoantibodies that cause Graves' hyperthyroidism, a common autoimmune disease in humans. Previously, we reported that pathogenic TSHR antibodies develop spontaneously in thyroiditis‐susceptible non‐obese diabe...

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Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: McLachlan, S. M., Aliesky, H. A., Banuelos, B., Lesage, S., Collin, R., Rapoport, B.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383439/
https://ncbi.nlm.nih.gov/pubmed/28099999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12928
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