Kinesin-4 KIF21B is a potent microtubule pausing factor

Microtubules are dynamic polymers that in cells can grow, shrink or pause, but the factors that promote pausing are poorly understood. Here, we show that the mammalian kinesin-4 KIF21B is a processive motor that can accumulate at microtubule plus ends and induce pausing. A few KIF21B molecules are s...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: van Riel, Wilhelmina E, Rai, Ankit, Bianchi, Sarah, Katrukha, Eugene A, Liu, Qingyang, Heck, Albert JR, Hoogenraad, Casper C, Steinmetz, Michel O, Kapitein, Lukas C, Akhmanova, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383399/
https://ncbi.nlm.nih.gov/pubmed/28290984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24746
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