Antitumor activity of a folate receptor-targeted immunoglobulin G-doxorubicin conjugate

Development of antibody-drug conjugates (ADCs) is a promising therapeutic strategy for cancer therapy. In this study, folate was conjugated via a polyethyleneglycol (PEG) linker to immunoglobulin G (IgG), which was linked to doxorubicin (DOX), to form a novel ADC folate-PEG-IgG-DOX (FA-PEG-IgG-DOX)....

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Yang, Tan, Xu, Ling, Li, Bin, Li, Weijie, Ma, Xiang, Fan, Lingling, Lee, Robert J, Xu, Chuanrui, Xiang, Guangya
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383082/
https://ncbi.nlm.nih.gov/pubmed/28408821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S125591
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