Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8(+) T Cells and Histone Acetyltransferases

NKG2D-mediated immune surveillance is crucial for inhibiting tumor growth and metastases. Malignant tumor cells often downregulate NKG2D ligands to escape from immune surveillance. High-profile studies have shown that restoring NKG2D ligand expression via genetic engineering inhibits tumor formation...

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Vydáno v:Cancer Immunol Res
Hlavní autoři: Hu, Jiemiao, Bernatchez, Chantale, Zhang, Liangfang, Xia, Xueqing, Kleinerman, Eugenie S, Hung, Mien-Chie, Hwu, Patrick, Li, Shulin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382872/
https://ncbi.nlm.nih.gov/pubmed/28223282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0234
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