CD8(+)T cell–specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution to CD8(+)T cell accumulation in tumors

BACKGROUND: Increased infiltration of CD8(+)T cells into tumors has a positive impact on survival. Our previous study showed that doxorubicin (Dox) plus interleukin-12 (IL-12) boosted the accumulation of CD8(+)T cells in tumors and had a greater antitumor effect than did either agent alone. The purp...

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Bibliographic Details
Main Authors: Hu, Jiemiao, Zhu, Shiguo, Xia, Xueqing, Zhang, Liangfang, Kleinerman, Eugenie S, Li, Shulin
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938086/
https://ncbi.nlm.nih.gov/pubmed/24565056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-34
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