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Protein Quality Control by Molecular Chaperones in Neurodegeneration

Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and their aggregates by protein quality control (PQC), of which molecular chaperones are an essential component. Compared with other cell types, PQC in neurons is particularly challenging because they have a uni...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Ciechanover, Aaron, Kwon, Yong Tae
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382173/
https://ncbi.nlm.nih.gov/pubmed/28428740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00185
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