Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability

Pancreatic ductal adenocarcinoma, which accounts for the majority of pancreatic cancers, is a lethal disease with few therapeutic options. Genomic profiling of pancreatic ductal adenocarcinoma has identified a complex and heterogeneous landscape. Understanding the molecular characteristics of pancre...

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Veröffentlicht in:PLoS One
Hauptverfasser: Stratford, Jeran K., Yan, Feng, Hill, Rebecca A., Major, Michael B., Graves, Lee M., Der, Channing J., Yeh, Jen Jen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381904/
https://ncbi.nlm.nih.gov/pubmed/28380042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174863
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