Comprehensive siRNA-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

Toll-like receptors (TLRs) are a major class of pattern recognition receptors, which mediate the response of innate immune cells to microbial stimuli. To systematically determine the roles of gene products in canonical TLR signaling pathways, we conducted an RNA interference (RNAi)-based screen in h...

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Bibliografske podrobnosti
izdano v:Sci Signal
Main Authors: Sun, Jing, Li, Ning, Oh, Kyu-Seon, Dutta, Bhaskar, Vayttaden, Sharat J., Lin, Bin, Ebert, Thomas S., De Nardo, Dominic, Davis, Joie, Bagirzadeh, Rustam, Lounsbury, Nicolas W., Pasare, Chandrashekhar, Latz, Eicke, Hornung, Veit, Fraser, Iain D. C.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381726/
https://ncbi.nlm.nih.gov/pubmed/26732763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab2191
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