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Effect of kynurenic acid on development and aging in wild type and vermilion mutants of Drosophila melanogaster
BACKGROUND: Up-regulation of tryptophan (Trp) conversion into kynurenine (Kyn) and increased formation of down-stream metabolites of Kyn is one of the mechanisms of aging and neurodegenerative disorders. Kyn is an immediate precursor of kynurenic acid (KYNA), an antagonist to NMDA and α7nAChR recept...
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| Publicado no: | Pharmacol Drug Dev Ther |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5381657/ https://ncbi.nlm.nih.gov/pubmed/28393115 |
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