The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction

Myocardial infarction (MI) dampens heart function and poses a great health risk. The class III deacetylase sirtuin 1 (SIRT1) is known to confer cardioprotection. SIRT1 expression is downregulated in the heart by a number of stress stimuli that collectively drive the pathogenesis of MI, although the...

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Pubblicato in:Nat Commun
Autori principali: Yang, Guang, Weng, Xinyu, Zhao, Yuhao, Zhang, Xinjian, Hu, Yuanping, Dai, Xin, Liang, Peng, Wang, Peng, Ma, LeiLei, Sun, Xiaolei, Hou, Lei, Xu, Huihui, Fang, Mingming, Li, Yuehua, Jenuwein, Thomas, Xu, Yong, Sun, Aijun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381011/
https://ncbi.nlm.nih.gov/pubmed/28361889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14941
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