FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch

Bruck Syndrome is a connective tissue disease associated with inactivating mutations in lysyl hydroxylase 2 (LH2/PLOD2) or FK506 binding protein 65 (FKBP65/FKBP10). However, the functional relationship between LH2 and FKBP65 remains unclear. Here, we postulated that peptidyl prolyl isomerase (PPIase...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Chen, Yulong, Terajima, Masahiko, Banerjee, Priyam, Guo, Houfu, Liu, Xin, Yu, Jiang, Yamauchi, Mitsuo, Kurie, Jonathan M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380960/
https://ncbi.nlm.nih.gov/pubmed/28378777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46021
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