Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury

Silybin is a secondary metabolite isolated from the seeds of blessed milk thistle (Silybum marianum) that has anti-inflammatory, antioxidative, antifibrotic, and antitumor properties. Here, we showed that silybin protected against cisplatin-induced acute kidney injury (AKI) by improving mitochondria...

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Vydáno v:Front Pharmacol
Hlavní autoři: Li, Yin, Ye, Zengchun, Lai, Weiyan, Rao, Jialing, Huang, Wanbing, Zhang, Xiaohao, Yao, Ziying, Lou, Tanqi
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380914/
https://ncbi.nlm.nih.gov/pubmed/28424621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00178
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