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Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis

OBJECTIVE(S): To explore the regulation mechanism of Sirtuin 3 (SIRT3) on the mitochondrial function and apoptosis of acute kidney injury (AKI) in septic mice. MATERIALS AND METHODS: The sepsis-induced AKI model was constructed in the wild-type and SIRT3 knockout (KO) mice, and the levels of serum c...

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Bibliografiske detaljer
Udgivet i:Iran J Basic Med Sci
Main Authors: Fan, Heng, Le, Jian-wei, Sun, Min, Zhu, Jian-hua
Format: Artigo
Sprog:Inglês
Udgivet: Mashhad University of Medical Sciences 2021
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244614/
https://ncbi.nlm.nih.gov/pubmed/34249270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/ijbms.2021.54905.12312
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