PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

Phosphoinositide-3-kinase and protein kinase B (PI3K-AKT) is upregulated in multiple myeloma (MM). Using a combination of short hairpin RNA (shRNA) lentivirus-mediated knockdown and pharmacologic isoform-specific inhibition we investigated the role of the PI3K p110γ (PI3Kγ) subunit in regulating MM...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Piddock, R E, Loughran, N, Marlein, C R, Robinson, S D, Edwards, D R, Yu, S, Pillinger, G E, Zhou, Z, Zaitseva, L, Auger, M J, Rushworth, S A, Bowles, K M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380901/
https://ncbi.nlm.nih.gov/pubmed/28282033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2017.16
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