FOXO1 couples metabolic activity and growth state in the vascular endothelium

Endothelial cells (ECs) are plastic cells that can switch between growth states with different bioenergetic and biosynthetic requirements(1). Although quiescent in most healthy tissues, ECs divide and migrate rapidly upon proangiogenic stimulation(2,3). Adjusting endothelial metabolism to growth sta...

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Pubblicato in:Nature
Autori principali: Wilhelm, Kerstin, Happel, Katharina, Eelen, Guy, Schoors, Sandra, Oellerich, Mark F., Lim, Radiance, Zimmermann, Barbara, Aspalter, Irene M., Franco, Claudio A., Boettger, Thomas, Braun, Thomas, Fruttiger, Marcus, Rajewsky, Klaus, Keller, Charles, Brüning, Jens C., Gerhardt, Holger, Carmeliet, Peter, Potente, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380221/
https://ncbi.nlm.nih.gov/pubmed/26735015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16498
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