Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ

The proinflammatory cytokine IL-36γ is highly expressed in epithelial cells and is a pivotal mediator of epithelial inflammation. In particular, IL-36γ is strongly associated with the inflammatory skin disease psoriasis. As with other IL-1 cytokines, IL-36γ is expressed as an inactive precursor and...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ainscough, Joseph S., Macleod, Tom, McGonagle, Dennis, Brakefield, Rosella, Baron, Jens M., Alase, Ade, Wittmann, Miriam, Stacey, Martin
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380102/
https://ncbi.nlm.nih.gov/pubmed/28289191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620954114
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