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Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis

BACKGROUND: IL-36γ is considered to be a valuable biomarker in psoriatic patients, which is expressed as an inactive precursor that needs to be proteolytically processed and activated, and neutrophil-derived proteases seemed to be potent activating enzymes of IL-36γ. OBJECTIVES: This study aims to i...

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Bibliografski detalji
Izdano u:Drug Des Devel Ther
Glavni autori: Guo, Jing, Tu, Jie, Hu, YingYing, Song, GuoXin, Yin, ZhiQiang
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372007/
https://ncbi.nlm.nih.gov/pubmed/30804664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S194765
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