Ligand-induced allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase

A heme-dependent conformational rearrangement of the C-terminal domain of heme binding protein (PhuS) is required for interaction with the iron-regulated heme oxygenase (HemO). Herein, we further investigate the underlying mechanism of this conformational rearrangement and its implications for heme...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Deredge, Daniel J., Huang, Weiliang, Hui, Colleen, Matsumura, Hirotoshi, Yue, Zhi, Moënne-Loccoz, Pierre, Shen, Jana, Wintrode, Patrick L., Wilks, Angela
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380046/
https://ncbi.nlm.nih.gov/pubmed/28289188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606931114
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