Small molecule selectively suppresses MYC transcription in cancer cells

Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription. Given the critical role the oncogene MYC plays in tumor initiation and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Bouvard, Claire, Lim, Sang Min, Ludka, John, Yazdani, Nahid, Woods, Ashley K., Chatterjee, Arnab K., Schultz, Peter G., Zhu, Shoutian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380033/
https://ncbi.nlm.nih.gov/pubmed/28292893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702663114
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