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A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells
Cancer cells with defects in DNA repair are highly susceptible to DNA-damaging agents, but delivery of therapeutic agents into cell nuclei can be challenging. A subset of lupus autoantibodies is associated with nucleolytic activity, and some of these antibodies are capable of nuclear penetration. We...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5380011/ https://ncbi.nlm.nih.gov/pubmed/25091037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05958 |
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