BSCI-04. TARGETING TRIPLE-NEGATIVE BREAST CANCER BRAIN METASTASES WITH A RE-ENGINEERED LUPUS AUTOANTIBODY

An unusual lupus anti-DNA autoantibody, 3E10, has potential to be used against triple-negative breast cancer (TNBC) brain metastases. 3E10 penetrates live cell nuclei, inhibits DNA repair, and is selectively toxic to cancer cells with the PTEN and/or DNA-damage response (DDR)-deficiencies that are a...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Neurooncol Adv
Main Authors: Zhang, Shenqi, May, Christopher, Shirali, Anupama, Dubljevic, Valentina, Campbell, James, Zhou, Jiangbing, Hansen, James
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213175/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz014.003
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki