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DNA-dependent targeting of cell nuclei by a lupus autoantibody
A nuclear-penetrating lupus anti-DNA autoantibody, 3E10, has been found to inhibit DNA repair and selectively kill certain cancer cells that are highly vulnerable to DNA damage. In addition, a 3E10 single chain variable fragment (scFv) has been developed for use as a delivery vehicle to carry therap...
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| Publicado no: | Sci Rep |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4496662/ https://ncbi.nlm.nih.gov/pubmed/26156563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12022 |
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