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Thiamin Diphosphate Activation in 1-Deoxy-D-xylulose 5-Phosphate Synthase: Insights into the Mechanism and Underlying Intermolecular Interactions

1-Deoxy-D-xylulose 5-phosphate synthase (DXS) is a thiamin diphosphate (TDP) dependent enzyme that marks the beginning of the methylerythritol 4-phosphate isoprenoid biosynthesis pathway. The mechanism of action for DXS is still poorly understood and begins with the formation of a thiazolium ylide....

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: White, Justin K., Handa, Sumit, Vankayala, Sai Lakshmana, Merkler, David J., Woodcock, H. Lee
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379999/
https://ncbi.nlm.nih.gov/pubmed/27537621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b07248
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