Proliferation of latently infected CD4(+) T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

A latent reservoir for HIV-1 in resting CD4(+) T lymphocytes precludes cure. Mechanisms underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of infected cell proliferation in vivo. T cell activation drives proliferation but also reverses latency, resulting in produ...

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Udgivet i:J Exp Med
Main Authors: Hosmane, Nina N., Kwon, Kyungyoon J., Bruner, Katherine M., Capoferri, Adam A., Beg, Subul, Rosenbloom, Daniel I.S., Keele, Brandon F., Ho, Ya-Chi, Siliciano, Janet D., Siliciano, Robert F.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379987/
https://ncbi.nlm.nih.gov/pubmed/28341641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170193
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