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Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants
Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior studies have revealed a common drug-binding region within the pore, but details about the binding sites and mechanism of block remain unclear. Her...
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| 發表在: | J Gen Physiol |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5379917/ https://ncbi.nlm.nih.gov/pubmed/28258204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611668 |
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