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Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics.

Many local anesthetics promote reduction in sodium current during repetitive stimulation of excitable membranes. Use-, frequency-, and voltage-dependent responses describe patterns of peak INa when pulse width, pulse frequency, and pulse amplitude are varied. Such responses can be viewed as reflecti...

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Detalhes bibliográficos
Main Authors: Starmer, C F, Grant, A O, Strauss, H C
Formato: Artigo
Idioma:Inglês
Publicado em: 1984
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1434933/
https://ncbi.nlm.nih.gov/pubmed/6331543
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