Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

BACKGROUND: Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of ∼100 common, low-penetrance PrCa susceptibility variants identified...

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Foilsithe in:Br J Cancer
Main Authors: Saunders, Edward J, Dadaev, Tokhir, Leongamornlert, Daniel A, Olama, Ali Amin Al, Benlloch, Sara, Giles, Graham G, Wiklund, Fredrik, Grönberg, Henrik, Haiman, Christopher A, Schleutker, Johanna, Nordestgaard, Børge G, Travis, Ruth C, Neal, David, Pasayan, Nora, Khaw, Kay-Tee, Stanford, Janet L, Blot, William J, Thibodeau, Stephen N, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong Y, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R, Pandha, Hardev, Govindasami, Koveela, Muir, Ken, Easton, Douglas F, Eeles, Rosalind A, Kote-Jarai, Zsofia
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
Ábhair:
Genetics and Genomics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379914/
https://ncbi.nlm.nih.gov/pubmed/26964030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.50
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