Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

BACKGROUND: Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of ∼100 common, low-penetrance PrCa susceptibility variants identified...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Saunders, Edward J, Dadaev, Tokhir, Leongamornlert, Daniel A, Olama, Ali Amin Al, Benlloch, Sara, Giles, Graham G, Wiklund, Fredrik, Grönberg, Henrik, Haiman, Christopher A, Schleutker, Johanna, Nordestgaard, Børge G, Travis, Ruth C, Neal, David, Pasayan, Nora, Khaw, Kay-Tee, Stanford, Janet L, Blot, William J, Thibodeau, Stephen N, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong Y, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R, Pandha, Hardev, Govindasami, Koveela, Muir, Ken, Easton, Douglas F, Eeles, Rosalind A, Kote-Jarai, Zsofia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379914/
https://ncbi.nlm.nih.gov/pubmed/26964030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.50
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