Transcription factor ZBP-89 drives a feedforward loop of β-catenin expression in colorectal cancer

In colorectal cancer (CRC), APC-mediated induction of unregulated cell growth involves post-translational mechanisms that prevent proteasomal degradation of proto-oncogene β-catenin (CTNNB1) and its eventual translocation to the nucleus. However, about 10 percent of colorectal tumors also exhibit in...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Essien, Bryan E., Sundaresan, Sinju, Ocadiz-Ruiz, Ramon, Chavis, Aaron, Tsao, Amy C., Tessier, Arthur J., Hayes, Michael M, Photenhauer, Amanda, Saqui-Salces, Milena, Kang, Anthony J., Shah, Yatrik M., Györffy, Balazs, Merchant, Juanita L.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379474/
https://ncbi.nlm.nih.gov/pubmed/27758879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3150
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