Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP)

Target-identification and understanding of mechanism-of-action (MOA) are challenging for development of small-molecule probes and their application in biology and drug discovery. For example, although aspirin has been widely used for more than 100 years, its molecular targets have not been fully cha...

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Udgivet i:Sci Rep
Main Authors: Wang, Jigang, Zhang, Chong-Jing, Zhang, Jianbin, He, Yingke, Lee, Yew Mun, Chen, Songbi, Lim, Teck Kwang, Ng, Shukie, Shen, Han-Ming, Lin, Qingsong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379034/
https://ncbi.nlm.nih.gov/pubmed/25600173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07896
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