Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP)

Target-identification and understanding of mechanism-of-action (MOA) are challenging for development of small-molecule probes and their application in biology and drug discovery. For example, although aspirin has been widely used for more than 100 years, its molecular targets have not been fully cha...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Wang, Jigang, Zhang, Chong-Jing, Zhang, Jianbin, He, Yingke, Lee, Yew Mun, Chen, Songbi, Lim, Teck Kwang, Ng, Shukie, Shen, Han-Ming, Lin, Qingsong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379034/
https://ncbi.nlm.nih.gov/pubmed/25600173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07896
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