Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP)

Target-identification and understanding of mechanism-of-action (MOA) are challenging for development of small-molecule probes and their application in biology and drug discovery. For example, although aspirin has been widely used for more than 100 years, its molecular targets have not been fully cha...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Wang, Jigang, Zhang, Chong-Jing, Zhang, Jianbin, He, Yingke, Lee, Yew Mun, Chen, Songbi, Lim, Teck Kwang, Ng, Shukie, Shen, Han-Ming, Lin, Qingsong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379034/
https://ncbi.nlm.nih.gov/pubmed/25600173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07896
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