Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptor...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Cai, Weikang, Sakaguchi, Masaji, Kleinridders, Andre, Gonzalez-Del Pino, Gonzalo, Dreyfuss, Jonathan M., O'Neill, Brian T., Ramirez, Alfred K., Pan, Hui, Winnay, Jonathon N., Boucher, Jeremie, Eck, Michael J., Kahn, C. Ronald
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378997/
https://ncbi.nlm.nih.gov/pubmed/28345670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14892
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker