Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens

Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood. We used HER2 as a model immunogen and reverse-engineered mu...

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Publié dans:Sci Rep
Auteurs principaux: Chen, Hong-Sen, Hou, Shin-Chen, Jian, Jhih-Wei, Goh, King-Siang, Shen, San-Tai, Lee, Yu-Ching, You, Jhong-Jhe, Peng, Hung-Pin, Kuo, Wen-Chih, Chen, Shui-Tsung, Peng, Ming-Chi, Wang, Andrew H.-J., Yu, Chung-Ming, Chen, Ing-Chien, Tung, Chao-Ping, Chen, Tzu-Han, Ping Chiu, Kuo, Ma, Che, Yuan Wu, Chih, Lin, Sheng-Wei, Yang, An-Suei
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378893/
https://ncbi.nlm.nih.gov/pubmed/26202883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12411
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