Constitutive IRAK4 Activation Underlies Poor Prognosis and Chemoresistance In Pancreatic Ductal Adenocarcinoma

PURPOSE: Aberrant activation of the NF-κB transcription factors underlies the aggressive behavior and poor outcome of pancreatic ductal adenocarcinoma (PDAC). However, clinically effective and safe NF-κB inhibitors are not yet available. Because NF-κB transcription factors can be activated by the In...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Zhang, Daoxiang, Li, Lin, Jiang, Hongmei, Knolhoff, Brett, Lockhart, Albert C., Wang-Gillam, Andrea, DeNardo, David G., Ruzinova, Marianna B., Lim, Kian-Huat
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378683/
https://ncbi.nlm.nih.gov/pubmed/27702822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1121
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