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IL-3 Up-regulates and Activates Human Eosinophil CD32 and αMß2 Integrin Causing Degranulation

BACKGROUND: Eosinophils contribute to the pathogenesis of multiple diseases, including asthma. Treatment with antibodies targeting IL-5 or IL-5 receptor α reduces the frequency of asthma exacerbations. Eosinophil receptors for IL-5 share a common ß-chain with IL-3 and GM-CSF receptors. We recently r...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Exp Allergy
Egile Nagusiak: Esnault, Stephane, Johansson, Mats W, Kelly, Elizabeth A., Koenderman, Leo, Mosher, Deane F, Jarjour, Nizar N
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378663/
https://ncbi.nlm.nih.gov/pubmed/28000949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.12876
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