IL-3 Up-regulates and Activates Human Eosinophil CD32 and αMß2 Integrin Causing Degranulation

BACKGROUND: Eosinophils contribute to the pathogenesis of multiple diseases, including asthma. Treatment with antibodies targeting IL-5 or IL-5 receptor α reduces the frequency of asthma exacerbations. Eosinophil receptors for IL-5 share a common ß-chain with IL-3 and GM-CSF receptors. We recently r...

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Bibliographic Details
Published in:Clin Exp Allergy
Main Authors: Esnault, Stephane, Johansson, Mats W, Kelly, Elizabeth A., Koenderman, Leo, Mosher, Deane F, Jarjour, Nizar N
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378663/
https://ncbi.nlm.nih.gov/pubmed/28000949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.12876
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