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A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular phenotypes in model systems expressing only a single VEGF isoform. ECM-immobilized VEGF can bind to and activate VEG...
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| Publicado en: | PLoS Comput Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5378411/ https://ncbi.nlm.nih.gov/pubmed/28319199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005445 |
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