WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3

The compound WP1066 was originally synthesized by modifying the structure of AG490, which inhibits the activation of signal transducer and activator of transcription 3 (STAT3) by directly targeting Janus kinases (JAKs). WP1066 exhibits stronger anti‐cancer activity than AG490 against malignant gliom...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Honda, Shino, Sadatomi, Daichi, Yamamura, Yasuo, Nakashioya, Kazutaka, Tanimura, Susumu, Takeda, Kohsuke
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378283/
https://ncbi.nlm.nih.gov/pubmed/28035720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13154
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