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Activation of MMP‐9 by membrane type‐1 MMP/MMP‐2 axis stimulates tumor metastasis
An artificial receptor for proMMP‐9 was created by fusing tissue inhibitor of MMP‐1 (TIMP‐1) with type II transmembrane mosaic serine protease (MSP‐T1). Expression of MSP‐T1 in 293T cells induced binding of proMMP‐9, which was processed by MMP‐2 activated by membrane type 1 MMP (MT1‐MMP). HT1080 cel...
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| Publié dans: | Cancer Sci |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5378257/ https://ncbi.nlm.nih.gov/pubmed/27987367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13134 |
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