A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation

DNA methylation is a key epigenetic modification involved in gene regulation whose contribution to disease susceptibility remains to be fully understood. Here, we present a novel Bayesian smoothing approach (called ABBA) to detect differentially methylated regions (DMRs) from whole-genome bisulfite...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Rackham, Owen J. L., Langley, Sarah R., Oates, Thomas, Vradi, Eleni, Harmston, Nathan, Srivastava, Prashant K., Behmoaras, Jacques, Dellaportas, Petros, Bottolo, Leonardo, Petretto, Enrico
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2017
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378105/
https://ncbi.nlm.nih.gov/pubmed/28213474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.195008
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