Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β(1)-Adrenergic Receptor N-terminal Cleavage

The β(1)-adrenergic receptor (β(1)AR) is a G protein-coupled receptor (GPCR) and the predominant adrenergic receptor subtype in the heart, where it mediates cardiac contractility and the force of contraction. Although it is the most important target for β-adrenergic antagonists, such as β-blockers,...

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發表在:J Biol Chem
Main Authors: Goth, Christoffer K., Tuhkanen, Hanna E., Khan, Hamayun, Lackman, Jarkko J., Wang, Shengjun, Narimatsu, Yoshiki, Hansen, Lasse H., Overall, Christopher M., Clausen, Henrik, Schjoldager, Katrine T., Petäjä-Repo, Ulla E.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2017
主題:
Cell Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377785/
https://ncbi.nlm.nih.gov/pubmed/28167537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.730614
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