Prostaglandin E(2) stimulates β1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-κB pathway

Prostaglandin E(2) (PGE(2)) has been implicated in cell invasion in hepatocellular carcinoma (HCC), via increased β1-integrin expression and cell migration; however, the mechanism remains unclear. PGE(2) exerts its effects via four subtypes of the E prostanoid receptor (EP receptor 1–4). The present...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Bai, Xiaoming, Wang, Jie, Guo, Yan, Pan, Jinshun, Yang, Qinyi, Zhang, Min, Li, Hai, Zhang, Li, Ma, Juan, Shi, Feng, Shu, Wei, Wang, Yipin, Leng, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377465/
https://ncbi.nlm.nih.gov/pubmed/25289898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06538
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