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Discovery of novel inhibitors of human S-adenosylmethionine decarboxylase based on in silico high-throughput screening and a non-radioactive enzymatic assay

Natural polyamines are small polycationic molecules essential for cell growth and development, and elevated level of polyamines is positively correlated with various cancers. As a rate-limiting enzyme of the polyamine biosynthetic pathway, S-adenosylmethionine decarboxylase (AdoMetDC) has been an at...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Liao, Chenzeng, Wang, Yanlin, Tan, Xiao, Sun, Lidan, Liu, Sen
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377238/
https://ncbi.nlm.nih.gov/pubmed/26030749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10754
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