A non‐canonical function of Ezh2 preserves immune homeostasis

Enhancer of zeste 2 (Ezh2) mainly methylates lysine 27 of histone‐H3 (H3K27me3) as part of the polycomb repressive complex 2 (PRC2) together with Suz12 and Eed. However, Ezh2 can also modify non‐histone substrates, although it is unclear whether this mechanism has a role during development. Here, we...

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Publicado no:EMBO Rep
Main Authors: Vasanthakumar, Ajithkumar, Xu, Dakang, Lun, Aaron TL, Kueh, Andrew J, van Gisbergen, Klaas PJM, Iannarella, Nadia, Li, Xiaofang, Yu, Liang, Wang, Die, Williams, Bryan RG, Lee, Stanley CW, Majewski, Ian J, Godfrey, Dale I, Smyth, Gordon K, Alexander, Warren S, Herold, Marco J, Kallies, Axel, Nutt, Stephen L, Allan, Rhys S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376973/
https://ncbi.nlm.nih.gov/pubmed/28223321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643237
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