Osteopontin attenuates aging‐associated phenotypes of hematopoietic stem cells

Upon aging, hematopoietic stem cells (HSCs) undergo changes in function and structure, including skewing to myeloid lineages, lower reconstitution potential and loss of protein polarity. While stem cell intrinsic mechanisms are known to contribute to HSC aging, little is known on whether age‐related...

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Udgivet i:EMBO J
Main Authors: Guidi, Novella, Sacma, Mehmet, Ständker, Ludger, Soller, Karin, Marka, Gina, Eiwen, Karina, Weiss, Johannes M, Kirchhoff, Frank, Weil, Tanja, Cancelas, Jose A, Florian, Maria Carolina, Geiger, Hartmut
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376966/
https://ncbi.nlm.nih.gov/pubmed/28254837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694969
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