Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia

In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch‐activated K(2P) potassium channel TREK‐1 (KCNK2 or K(2P)2.1). This mutation introduces abnormal sodium permeability to TREK‐1. In addition, mutan...

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Enregistré dans:
Détails bibliographiques
Publié dans:EMBO Mol Med
Auteurs principaux: Decher, Niels, Ortiz‐Bonnin, Beatriz, Friedrich, Corinna, Schewe, Marcus, Kiper, Aytug K, Rinné, Susanne, Seemann, Gunnar, Peyronnet, Rémi, Zumhagen, Sven, Bustos, Daniel, Kockskämper, Jens, Kohl, Peter, Just, Steffen, González, Wendy, Baukrowitz, Thomas, Stallmeyer, Birgit, Schulze‐Bahr, Eric
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376757/
https://ncbi.nlm.nih.gov/pubmed/28242754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606690
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