Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show transcriptomic differences in synovial fibroblasts from different joint locations and that HOX gene signatures reflect the joint-specific origins of mous...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Frank-Bertoncelj, Mojca, Trenkmann, Michelle, Klein, Kerstin, Karouzakis, Emmanuel, Rehrauer, Hubert, Bratus, Anna, Kolling, Christoph, Armaka, Maria, Filer, Andrew, Michel, Beat A., Gay, Renate E., Buckley, Christopher D., Kollias, George, Gay, Steffen, Ospelt, Caroline
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376654/
https://ncbi.nlm.nih.gov/pubmed/28332497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14852
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