Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show transcriptomic differences in synovial fibroblasts from different joint locations and that HOX gene signatures reflect the joint-specific origins of mous...

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Vydáno v:Nat Commun
Hlavní autoři: Frank-Bertoncelj, Mojca, Trenkmann, Michelle, Klein, Kerstin, Karouzakis, Emmanuel, Rehrauer, Hubert, Bratus, Anna, Kolling, Christoph, Armaka, Maria, Filer, Andrew, Michel, Beat A., Gay, Renate E., Buckley, Christopher D., Kollias, George, Gay, Steffen, Ospelt, Caroline
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376654/
https://ncbi.nlm.nih.gov/pubmed/28332497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14852
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